Serotonin-kynurenine hypothesis of depression: historical overview and recent developments.

  title={Serotonin-kynurenine hypothesis of depression: historical overview and recent developments.},
  author={G. Oxenkrug},
  journal={Current drug targets},
  volume={14 5},
  • G. Oxenkrug
  • Published 2013
  • Medicine
  • Current drug targets
  • This mini-review focuses on the studies of late Prof. IP Lapin (1903 - 2012) and his research team on the role of methoxyindole and kynurenine (KYN) pathways of tryptophan (TRP) metabolism in the pathogenesis of depression and action mechanisms of antidepressant effect. In the late 60s of the last century Prof. IP Lapin suggested that "intensification of central serotoninergic processes is a determinant of the thymoleptic (mood elevating) component" while "activation of noradrenergic processes… CONTINUE READING
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