Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes.

@article{Arzt1991SerotoninIO,
  title={Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes.},
  author={Eduardo Arzt and M{\'o}nica Alejandra Costas and Samuel Finkielman and V{\'i}ctor E. Nahmod},
  journal={Life sciences},
  year={1991},
  volume={48 26},
  pages={
          2557-62
        }
}
Serotonin inhibited in a concentration dependent way (10(-3) M to 10(-10) M) the LPS induced Tumor Necrosis Factor-alpha synthesis both, when added to the monocyte cultures from the beginning and when added together with the activating stimulus 8 hours before the end of the culture. The inhibitory effect was specifically blocked by the 5-HT1 and 5-HT2 serotonin antagonist methysergide and the 5-HT2 receptor antagonist ketanserin. This indicates that only the 5-HT2 receptor family (5-HT2 or 5… CONTINUE READING

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