Serotonin induces melanogenesis via serotonin receptor 2A.

  title={Serotonin induces melanogenesis via serotonin receptor 2A.},
  author={Hyun Joo Lee and Myoung Kyu Park and Su Young Kim and Hea-Young Park Choo and Ai Young Lee and Chul Hee Lee},
  journal={The British journal of dermatology},
  volume={165 6},
BACKGROUND Serotonin (5-hydroxytryptamine, 5-HT) levels are increased by light exposure but the role and mechanism of 5-HT in the pigmentation of skin cells are unclear. OBJECTIVES To clarify the effect of 5-HT on melanogenesis and to determine the 5-HT receptor subtype involved. METHODS B16F10, SK-MEL-2 and Melan-A cells were cultured in Dulbecco's modified Eagle's medium with low fetal bovine serum. The three cell lines were treated with various concentrations of 5-HT, and 5-HT receptor… CONTINUE READING


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