Serotonin-induced potentiation of cholinergic responses to electrical field stimulation in normal and neurogenic overactive human detrusor muscle.

@article{Chapple2004SerotonininducedPO,
  title={Serotonin-induced potentiation of cholinergic responses to electrical field stimulation in normal and neurogenic overactive human detrusor muscle.},
  author={Christopher R Chapple and Stephen C. Radley and Scott W Martin and Donna J Sellers and Russell Chess-Williams},
  journal={BJU international},
  year={2004},
  volume={93 4},
  pages={599-604}
}
OBJECTIVE To compare the serotonin (5-HT)4-receptor-mediated effects of 5-HT on the potentiation of cholinergic responses to electrical-field stimulation (EFS) in isolated strips of detrusor muscle from patients with normal or neurogenic overactive bladders. MATERIAL AND METHODS Strips of detrusor muscle were field-stimulated (10 Hz, 0.01 ms duration, 60 V for 5 s) at 100-s intervals until consistent responses were obtained. In the presence of methiothepin, ketanserin and ondansetron (all 1… CONTINUE READING