Serotonin increases macrophage uptake of oxidized low density lipoprotein.

  title={Serotonin increases macrophage uptake of oxidized low density lipoprotein.},
  author={Michael Y Aviram and Bianca Fuhrman and Irit Maor and Gerald J. Brook},
  journal={European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies},
  volume={30 2},
Macrophage uptake of oxidized low density lipoprotein leads to cellular cholesterol accumulation and foam cell formation. Atherogenesis involves platelet activation with subsequent serotonin release. Incubation of J-774 A.1 murine macrophages as well as mouse peritoneal macrophages with serotonin for 2-18 hours at 37 degrees C, followed by cell wash and a further incubation of the cells for 18 hours in the presence of oxidized LDL (protein concentration 10-75 mg/l), resulted in up to 85… CONTINUE READING