Serotonin in the inferior colliculus

  title={Serotonin in the inferior colliculus},
  author={Laura M. Hurley and Ann M. Thompson and George D. Pollak},
  journal={Hearing Research},

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Serotonin modulates responses to species-specific vocalizations in the inferior colliculus

The effects of iontophoretically applied serotonin on the responses of individual inferior colliculus neurons to a variety of recorded species-specific vocalizations were examined and it was found that a functional consequence of these serotonin-evoked changes would be to change the population response to species- specific vocalizations.

Serotonergic modulation of inhibitory synaptic transmission in mouse inferior colliculus.

The findings suggest that serotonin is endogenously released even in slice preparations, and it negatively modulates the tone of activity of inhibitory neurons within IC, and suggests that the serotonergic input may contribute to pathological conditions such as tinnitus.

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The results support the general conclusion that changes in latency are an important part of the neuromodulatory repertoire of serotonin within the auditory system and show that serotonin can change latency either in conjunction with broad changes in other aspects of neuronal excitability or in highly specific ways.

Neuropeptide Y Expression Defines a Novel Class of GABAergic Projection Neuron in the Inferior Colliculus

NPY neurons are a novel class of inhibitory neurons that use GABA and NPY signaling to regulate activity in the IC and auditory thalamus, and hyperpolarized the membrane potential of a subset of excitatory IC neurons that express the NPY Y1 receptor.

Modulation of auditory brainstem responses by serotonin and specific serotonin receptors

Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

  • L. Hurley
  • Biology, Psychology
    Journal of neurophysiology
  • 2006
Evidence suggests that the diversity of serotonin receptor sub types in the IC is likely to account for at least some of the variability of the effects of serotonin and that receptor subtypes fulfill specialized roles in auditory processing.

Serotonergic Modulation of Sensory and Multisensory Processing in Superior Colliculus

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The results suggest that serotonin, whose release varies with behavioral state, functionally reconfigures the circuitry of the IC and may modulate the perception of acoustic signals under different behavioral states.

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The present neuroanatomic and neurochemical findings support behavioral and neurophysiologic findings that the serotonergic system may modulate central auditory processing.