Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential.

@article{Basu2008SerotoninIP,
  title={Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential.},
  author={Basudha Basu and Radha Desai and Jayaprakash Balaji and Raghothama Chaerkady and Venkataraman Sriram and Sudipta Maiti and Mitradas M. Panicker},
  journal={Reproduction},
  year={2008},
  volume={135 5},
  pages={657-69}
}
Serotonin is reported to be present in early embryos of many species and plays an important role in early patterning. Since it is a fluorophore, it can be directly visualized using fluorescence microscopy. Here, we use three-photon microscopy to image serotonin in live pre-implantation mouse embryos. We find that it is present as puncta averaging 1.3 square microns and in concentrations as high as 442 mM. The observed serotonin puncta were found to co-localize with mitochondria. Live embryos… CONTINUE READING

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