Serotonin has a key role in pathogenesis of experimental colitis.

@article{Ghia2009SerotoninHA,
  title={Serotonin has a key role in pathogenesis of experimental colitis.},
  author={J. Ghia and N. Li and H. Wang and M. Collins and Yikang Deng and R. El-Sharkawy and F. C{\^o}t{\'e} and J. Mallet and W. Khan},
  journal={Gastroenterology},
  year={2009},
  volume={137 5},
  pages={
          1649-60
        }
}
BACKGROUND & AIMS Mucosal changes in inflammatory bowel disease are characterized by ulcerative lesions accompanied by a prominent infiltrate of immune cells as well as alteration in serotonin (5-hydroxytryptamine [5-HT])-producing enterochromaffin cells. We investigated the role of 5-HT in colonic inflammation in mice. METHODS Colitis was induced with dextran sulfate sodium or dinitrobenzene sulfonic acid in tryptophan hydroxylase 1-deficient (TPH1(-/-)) mice, which have markedly reduced 5… Expand
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240 Citations
Highly Influential Citations
10
Background Citations
94
Methods Citations
9
Results Citations
5

Paper Mentions

Observational Clinical Trial
Investigating Serotonin Signalling in IBD Patients
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in… Expand
ConditionsInflammatory Bowel Disease
McMaster University
July 2012 - May 2021

240 Citations

Citation Type

Citation Type

Interleukin 13 and Serotonin: Linking the Immune and Endocrine Systems in Murine Models of Intestinal Inflammation
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Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation
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The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter.
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  • Highly Influenced
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Serotonin 5-HT7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract
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Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.
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Effects of ketanserin on experimental colitis in mice and macrophage function
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Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine
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Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon
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Serotonin activates dendritic cell function in the context of gut inflammation.
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Dual Role of Endogenous Serotonin in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis
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