Serotonin has a key role in pathogenesis of experimental colitis.

@article{Ghia2009SerotoninHA,
  title={Serotonin has a key role in pathogenesis of experimental colitis.},
  author={J. Ghia and N. Li and H. Wang and M. Collins and Yikang Deng and R. El-Sharkawy and F. C{\^o}t{\'e} and J. Mallet and W. Khan},
  journal={Gastroenterology},
  year={2009},
  volume={137 5},
  pages={
          1649-60
        }
}
BACKGROUND & AIMS Mucosal changes in inflammatory bowel disease are characterized by ulcerative lesions accompanied by a prominent infiltrate of immune cells as well as alteration in serotonin (5-hydroxytryptamine [5-HT])-producing enterochromaffin cells. We investigated the role of 5-HT in colonic inflammation in mice. METHODS Colitis was induced with dextran sulfate sodium or dinitrobenzene sulfonic acid in tryptophan hydroxylase 1-deficient (TPH1(-/-)) mice, which have markedly reduced 5… Expand
240 Citations

Paper Mentions

Observational Clinical Trial
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in… Expand
ConditionsInflammatory Bowel Disease
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