Serotonin function in affective disorders.

  title={Serotonin function in affective disorders.},
  author={David G. Grahame-Smith},
  journal={Acta psychiatrica Scandinavica. Supplementum},
The evidence indicating a specific abnormality of brain 5-HT function in depressed patients is reviewed. Biochemical studies have indicated that low plasma levels of tryptophan are unlikely to be the primary 'cause' of depression or of abnormal brain 5-HT function in depression. However, there may be a reduction of 5-HT synthesis or function in the brains of depressed patients and the uptake of 5-HT into platelets from depressed patients is consistently reduced. Neuroendocrine studies have… CONTINUE READING

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