Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses.

Abstract

5-HT(2)-type serotonin receptors (5-HT(2)Rs) are widely expressed throughout the brain and mediate many of the modulatory effects of serotonin. It has been thought that postsynaptic 5-HT(2)Rs act primarily by depolarizing neurons and thereby increasing their excitability. However, it is also known that 5-HT(2)Rs are coupled to G(q/11)-type G-proteins and… (More)
DOI: 10.1523/JNEUROSCI.0678-08.2008

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