Serotonin-dopamine interaction and its relevance to schizophrenia.

  title={Serotonin-dopamine interaction and its relevance to schizophrenia.},
  author={S. Kapur and G. Remington},
  journal={The American journal of psychiatry},
  volume={153 4},
  • S. Kapur, G. Remington
  • Published 1996
  • Psychology, Medicine
  • The American journal of psychiatry
  • OBJECTIVE The therapeutic success of clozapine and risperidone has focused attention on the interaction between serotonin and dopamine systems as an avenue for superior therapeutics in schizophrenia. The authors review the neurobiological basis for this interaction and its clinical relevance. METHOD The authors synthesized information from more than 100 published articles obtained through electronic and bibliography-directed searches. FINDINGS The serotonin system inhibits dopaminergic… CONTINUE READING
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