Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice.

@article{Koyama2006SerotoninDM,
  title={Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice.},
  author={Naoto Koyama and Kanna Kuribayashi and Tetsuya Seki and Katsunori Kobayashi and Yasufumi Furuhata and Katsuya Suzuki and Harumi Arisaka and Takashi Nakano and Yusuke Amino and Koichi Ishii},
  journal={Journal of agricultural and food chemistry},
  year={2006},
  volume={54 14},
  pages={4970-6}
}
The effects of defatted safflower seed extract and its phenolic constituents, serotonin derivatives, on atherosclerosis were studied. Ethanol-ethyl acetate extract of safflower seeds (SSE) inhibited low-density lipoprotein (LDL) oxidation induced in vitro by an azo-containing free-radical initiator V70 or copper ions. Two serotonin derivatives [N-(p-coumaroyl)serotonin, CS; N-feruloylserotonin, FS] and their glucosides were identified as the major phenolic constituents of the extract. The study… CONTINUE READING

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