Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits

@article{Mazer1997SerotoninDD,
  title={Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits},
  author={Carrie Mazer and Jennifer Muneyyirci and Kenneth Taheny and Nicholas Raio and Patricia Mack Whitaker-Azmitia},
  journal={Brain Research},
  year={1997},
  volume={760},
  pages={68-73}
}
Studies in the past have revealed serotonin to play a role in regulating the development and maturation of the mammalian brain, largely through the release of the astroglial protein S-100beta. S-100beta plays a role in neurite extension, microtubule and dendritic stabilization and regulation of the growth associated protein GAP-43, all of which are key elements in the production of synapses. Depletion of serotonin, and thus of S-100beta, during synaptogenesis should lead to a loss of synapses… CONTINUE READING
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