Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices.

@article{Corradetti1992SerotoninBT,
  title={Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices.},
  author={Renato Corradetti and Laura Ballerini and Anna Maria Pugliese and Giancarlo Pepeu},
  journal={Neuroscience},
  year={1992},
  volume={46 3},
  pages={511-8}
}
The effect of 5-hydroxytryptamine on the induction of long-term potentiation by a train of high frequency pulses (100 Hz; 1 s) or by a stimulation consisting of one burst of five pulses at 100 Hz delivered 170 ms after a single pulse (primed burst) was investigated in the CA1 region of the rat hippocampal slice in vitro with extracellular recordings. Superfusion with 5-hydroxytryptamine (3-30 microM) produced a concentration-dependent decrease in amplitude of the population spikes evoked by… CONTINUE READING
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