Serotonin autoreceptor function and antidepressant drug action

  title={Serotonin autoreceptor function and antidepressant drug action},
  author={S. Hjorth and H. Bengtsson and Anders Kullberg and Daniel Carlzon and Helena Peilot and Sidney B. Auerbach},
  journal={Journal of Psychopharmacology},
  pages={177 - 185}
This article briefly summarizes, within the context of a brief review of the relevant literature, the outcome of our recent rat microdialysis studies on (1) the relative importance of serotonin (5-HT)1A versus 5-HT1B autoreceptors in the mechanism of action of 5-HT reuptake blocking agents, including putative regional differences in this regard, and (2) autoreceptor responsiveness following chronic SSRI administration. First, our data are consistent with the primacy of 5-HT1A autoreceptors in… 

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