Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function.

@article{Dinan1996SerotoninAT,
  title={Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function.},
  author={Timothy G Dinan},
  journal={Life sciences},
  year={1996},
  volume={58 20},
  pages={
          1683-94
        }
}
That serotonin (5HT) is involved in regulating hypothalamic-pituitary- adrenal axis (HPA) function has long been recognized. A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations. There is a general assumption that such stimulation occurs at a hypothalamic level. However, our increasing understanding of the complex interplay between 5HT… CONTINUE READING
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