Serotonin and serotonin receptors in hallucinogen action

  title={Serotonin and serotonin receptors in hallucinogen action},
  author={Adam L. Halberstadt and David E. Nichols},
  journal={Handbook of Behavioral Neuroscience},

(MDMA): current perspectives

Even though MDMA is listed as a Schedule I compound by the Drug Enforcement Agency, MDMA-assisted psychotherapy for patients with chronic, treatment-resistant posttraumatic stress disorder is currently under investigation and initial results show efficacy for this treatment approach, although considerably more research must be formed to confirm such efficacy.

Psychostimulants: Basic and Clinical Pharmacology.

Absence of a significant interaction of two common NOS1 and 5-HTT polymorphisms on sensorimotor gating in humans.

The combined genetic effects of NOS1 Ex1f-VNTR and 5-HTTLPR on sensorimotor gating, measured by prepulse inhibition (PPI) of the acoustic startle reflex, in 164 healthy adults are investigated.

Serotonin and consciousness – A reappraisal

  • C. Müller
  • Psychology, Biology
    Behavioural Brain Research
  • 2022

Non-pharmacological factors that determine drug use and addiction

Drug instrumentalization

  • C. Müller
  • Psychology, Biology
    Behavioural Brain Research
  • 2020

Drugs as instruments: A new framework for non-addictive psychoactive drug use

It is argued that drug instrumentalization behavior may provide a functional adaptation to modern environments based on a historical selection for learning mechanisms that allow the dynamic modification of consummatory behavior.



Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice

It is confirmed that psilocin acts as an agonist at 5-HT1A, 4-hydroxy-N,N-dimethyltryptamine, and 5- HT2C receptors in mice, whereas the behavioral effects of 1-methylpsilocin indicate that this compound is acting at5-HT2A sites but is inactive at the 5-ht1A receptor.


  • D. Nichols
  • Psychology, Biology
    Pharmacological Reviews
  • 2016
Blood oxygen level–dependent functional magnetic resonance imaging and magnetoencephalography have been employed for in vivo brain imaging in humans after administration of a psychedelic, and results indicate that intravenously administered psilocybin and LSD produce decreases in oscillatory power in areas of the brain’s default mode network.

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.

Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats.

It is suggested that (+)MDMA increases locomotor activity via mechanisms that are dependent on the release of central 5-HT and that are qualitatively different from the mechanism of action of (+)amphetamine.

Do classical hallucinogens act as 5-HT2 agonists or antagonists?

  • R. Glennon
  • Biology
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1990
A review of the existing literature suggests that where a 5-HT2 mechanism has been implicated (such as in phosphoinositide turnover, contraction of certain smooth muscle, rat-paw edema, head-twitch behavior, discriminative stimulus effects, hyperthermia, platelet aggregation, and in various other effects), the classical hallucinogens are most likely acting via an agonist, or at least via a partial agonists mechanism.

A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA

Methylenedioxymethamphetamine (MDMA) is a phenylethylamine with a chemical structure that resembles both the amphetamines and mescaline and has both stimulant and perception altering properties. The