Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors

@article{Mller2007SerotoninAP,
  title={Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors},
  author={Christian P. M{\"u}ller and Robert J. Carey and Joseph P. Huston and Maria Ang{\'e}lica de Souza Silva},
  journal={Progress in Neurobiology},
  year={2007},
  volume={81},
  pages={133-178}
}

Role of serotonin 5-HT1B receptors in psychostimulant addiction.

TLDR
The role of 5-HT(1B) receptors in the psychostimulant addiction is discussed on the base of the effects of 6-HT (5-HT) receptor ligands on the behavioral effects of the psychOSTimulants in experimental models used to assess their addictive properties.

Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

TLDR
These data indicate that 5-HT2C receptors within the mPFC and the NAC modulate the reinforcing effects of cocaine and provide evidence that5- HT2C receptor agonists could be a possible drug discovery target for the treatment of psychostimulant addiction.

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

TLDR
The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.

5-HT7 receptors in the modulation of cognitive processes

Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro

TLDR
These findings reveal a novel regulatory component in the actions of MDMA and represent the first demonstration that 5-HT2B receptors play an important role in the brain, i.e., modulation of 5- HT release, and may serve as promising therapeutic drugs for MDMA abuse.

The role of serotoninergic system in psychostimulant effects

TLDR
The pharmacological manipulation of serotonergic system activity makes it possible to attenuate the effects of psychostimulants, which gives hope for the development of effective pharmacotherapy.

Neuroadaptive Changes in  5-HT1A Autoreceptor Sensitivity  Following High-Dose MDMA Treatment

TLDR
The results do not indicate an increase in sensitivity of the 5-HT1A autoreceptor, and hence the original hypothesis is not supported, and there were a number of methodological issues, as indicated by the lack of MDMAinduced 5-HT deficits, which prevent a firm conclusion from being drawn.
...

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