Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors

  title={Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors},
  author={Christian P. M{\"u}ller and Robert J. Carey and Joseph P. Huston and Maria Ang{\'e}lica de Souza Silva},
  journal={Progress in Neurobiology},

Role of serotonin 5-HT1B receptors in psychostimulant addiction.

The role of 5-HT(1B) receptors in the psychostimulant addiction is discussed on the base of the effects of 6-HT (5-HT) receptor ligands on the behavioral effects of the psychOSTimulants in experimental models used to assess their addictive properties.

Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

These data indicate that 5-HT2C receptors within the mPFC and the NAC modulate the reinforcing effects of cocaine and provide evidence that5- HT2C receptor agonists could be a possible drug discovery target for the treatment of psychostimulant addiction.

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.

5-HT7 receptors in the modulation of cognitive processes

Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro

These findings reveal a novel regulatory component in the actions of MDMA and represent the first demonstration that 5-HT2B receptors play an important role in the brain, i.e., modulation of 5- HT release, and may serve as promising therapeutic drugs for MDMA abuse.

The role of serotoninergic system in psychostimulant effects

The pharmacological manipulation of serotonergic system activity makes it possible to attenuate the effects of psychostimulants, which gives hope for the development of effective pharmacotherapy.

Neuroadaptive Changes in  5-HT1A Autoreceptor Sensitivity  Following High-Dose MDMA Treatment

The results do not indicate an increase in sensitivity of the 5-HT1A autoreceptor, and hence the original hypothesis is not supported, and there were a number of methodological issues, as indicated by the lack of MDMAinduced 5-HT deficits, which prevent a firm conclusion from being drawn.

5-HT receptors and reward-related behaviour: A review




MDMA induced dopamine release in vivo: role of endogenous serotonin

It is concluded that 5-HT release after (+)-MDMA treatment partially contributes to (+-MDMA's effect on DA release in vivo, and the selective DA transport inhibitor GBR-12909 (1 μM), blocked (+)- MDMA’s effect onDA release.

Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.

  • L. HeislerH. Chu L. Tecott
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
Results indicate that the targeted disruption of the 5-HT1A receptor gene leads to heritable perturbations in the serotonergic regulation of emotional state.

Postsynaptic 5-HT1A receptors mediate an increase in locomotor activity in the monoamine-depleted rat

The present data indicate that R-(+)-8-OHDPAT can increase motor activity in monoamine-depleted rats through postsynaptic 5- HT1A receptors and not necessarily through 5-HT1A autoreceptor-mediated alterations in5-HT synthesis and release.

5-HT system and cognition

  • A. Meneses
  • Biology
    Neuroscience & Biobehavioral Reviews
  • 1999

Serotonin and drug reward: focus on 5-HT2C receptors.