Serotonin and pancreatic duct function.

  title={Serotonin and pancreatic duct function.},
  author={S. Naruse and A. Suzuki and H. Ishiguro and M. Kitagawa and S. Ko and T. Yoshikawa and A. Yamamoto and H. Hamada and T. Hayakawa},
  journal={Journal of Korean Medical Science},
  pages={S27 - S28}
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the… Expand
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