Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid.

@article{Pini1997SerotoninAO,
  title={Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid.},
  author={Luigi Alberto Pini and Giovanni Vitale and Maurizio Sandrini},
  journal={Pharmacology},
  year={1997},
  volume={54 2},
  pages={84-91}
}
Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test. ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT2 receptors in cortical brain membranes 30 min after drug administration. Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2… CONTINUE READING
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