Serotonin and neuropeptide F have opposite modulatory effects on fly aggression

@article{Dierick2007SerotoninAN,
  title={Serotonin and neuropeptide F have opposite modulatory effects on fly aggression},
  author={Herman A. Dierick and Ralph J. Greenspan},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={678-682},
  url={https://api.semanticscholar.org/CorpusID:33768246}
}
It is shown in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropePTide Y, modulate aggression, and the implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior.
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293 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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293 Citations

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31 References

Y1 receptors regulate aggressive behavior by modulating serotonin pathways.

The results suggest that NPY acting through Y1 receptors regulates the 5-HT system, thereby coordinately linking physiological survival mechanisms such as food intake with enabling territorial aggressive behavior.

Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity.

A Drosophila signaling system, comprising neurons expressing neuropeptide F and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation is identified, providing the molecular and neural basis for the strikingly similar alcohol-responsive behaviors between flies and mammals.

Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila

It is proposed that NPF also plays a role in clock-controlled sexual dimorphism in adult Drosophila, and is under dual regulation by circadian and sex-determining factors.

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A

From genes to aggressive behavior: the role of serotonergic system.

This paper concentrates on the involvement of protein elements in the brain neurotransmitter serotonin (5-HT) system in the genetic control of aggressive behavior and provides converging lines of evidence that brain 5-HT contributes to a critical mechanism underlying genetically defined individual differences in aggressiveness.

Neuropeptide y: role in emotion and alcohol dependence.

The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined.

Drosophila as a new model organism for the neurobiology of aggression?

Drosophila, with its advanced set of molecular tools and its behavioural richness, has the potential to develop into a new model organism for the study of the neurobiology of aggression.

The spectrum of behaviors influenced by serotonin

Regulation of aversion to noxious food by Drosophila neuropeptide Y– and insulin-like systems

The results suggest that the coordinated activities of the conserved NPY- and insulin-like receptor signaling systems are essential for the dynamic regulation of noxious food intake according to the animal's energy state.