Serotonin and neuropeptide F have opposite modulatory effects on fly aggression

  title={Serotonin and neuropeptide F have opposite modulatory effects on fly aggression},
  author={Herman A. Dierick and Ralph J. Greenspan},
  journal={Nature Genetics},
Both serotonin (5-HT) and neuropeptide Y have been shown to affect a variety of mammalian behaviors, including aggression. Here we show in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropeptide Y, modulate aggression. We show that drug-induced increases of 5-HT in the fly brain increase aggression. Elevating 5-HT genetically in the serotonergic circuits recapitulates these pharmacological effects, whereas genetic silencing of these circuits makes the… 
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  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
The results suggest that NPY acting through Y1 receptors regulates the 5-HT system, thereby coordinately linking physiological survival mechanisms such as food intake with enabling territorial aggressive behavior.
Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity.
A Drosophila signaling system, comprising neurons expressing neuropeptide F and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation is identified, providing the molecular and neural basis for the strikingly similar alcohol-responsive behaviors between flies and mammals.
Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila
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A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A
From genes to aggressive behavior: the role of serotonergic system.
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    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2006
This paper concentrates on the involvement of protein elements in the brain neurotransmitter serotonin (5-HT) system in the genetic control of aggressive behavior and provides converging lines of evidence that brain 5-HT contributes to a critical mechanism underlying genetically defined individual differences in aggressiveness.
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The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined.
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  • Psychology, Biology
    Biological Psychiatry
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The results suggest that the coordinated activities of the conserved NPY- and insulin-like receptor signaling systems are essential for the dynamic regulation of noxious food intake according to the animal's energy state.