Serotonin and neuropeptide F have opposite modulatory effects on fly aggression

  title={Serotonin and neuropeptide F have opposite modulatory effects on fly aggression},
  author={H. Dierick and R. Greenspan},
  journal={Nature Genetics},
  • H. Dierick, R. Greenspan
  • Published 2007
  • Biology, Medicine
  • Nature Genetics
  • Both serotonin (5-HT) and neuropeptide Y have been shown to affect a variety of mammalian behaviors, including aggression. Here we show in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropeptide Y, modulate aggression. We show that drug-induced increases of 5-HT in the fly brain increase aggression. Elevating 5-HT genetically in the serotonergic circuits recapitulates these pharmacological effects, whereas genetic silencing of these circuits makes the… CONTINUE READING
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