Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
@article{Dierick2007SerotoninAN, title={Serotonin and neuropeptide F have opposite modulatory effects on fly aggression}, author={Herman A Dierick and Ralph J. Greenspan}, journal={Nature Genetics}, year={2007}, volume={39}, pages={678-682} }
Both serotonin (5-HT) and neuropeptide Y have been shown to affect a variety of mammalian behaviors, including aggression. Here we show in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropeptide Y, modulate aggression. We show that drug-induced increases of 5-HT in the fly brain increase aggression. Elevating 5-HT genetically in the serotonergic circuits recapitulates these pharmacological effects, whereas genetic silencing of these circuits makes the…
272 Citations
Serotonin 5-HT2 and 5-HT1A-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster
- Biology, PsychologyNeuroscience
- 2009
Single Serotonergic Neurons that Modulate Aggression in Drosophila
- Biology, PsychologyCurrent Biology
- 2014
Sex differences in aggression: Differential roles of 5-HT2, neuropeptide F and tachykinin
- Biology, PsychologyPloS one
- 2019
A more nuanced role for 5-HT in modulating aggression in invertebrates is demonstrated, revealing an important interactive role with neuropeptides that is more reminiscent of vertebrates.
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster
- Biology, PsychologyNeural plasticity
- 2016
The results demonstrate that disruption of components within the 5-HT system significantly impairs locomotion and feeding behaviors in larvae and that fluoxetine can significantly decrease the sensory-motor activity.
Sex Differences in Aggression: Differential Roles of 5-HT2, Neuropeptide F and Tachykinin
- Biology, PsychologybioRxiv
- 2018
A more nuanced role for 5-HT in modulating aggression in invertebrates is demonstrated, revealing an important interactive role with neuropeptides that is more reminiscent of vertebrates.
Targeted Manipulation of Serotonergic Neurotransmission Affects the Escalation of Aggression in Adult Male Drosophila melanogaster
- Biology, PsychologyPloS one
- 2010
Evidence is collected demonstrating a direct role for 5HT in the escalation of aggression in Drosophila by separately manipulating 5HT- and DA- neuron systems.
A neuropeptide regulates fighting behavior in Drosophila melanogaster
- Biology, PsychologyeLife
- 2020
It is found that the neuropeptide Drosulfakinin (Dsk) modulates aggression in Drosophila melanogaster and this work suggests a conserved neuromodulatory system for the modulation of aggressive behavior.
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways
- BiologyCurrent Biology
- 2019
A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila
- Biology, PsychologyPloS one
- 2016
The results reveal that compensation can occur on the circuit level and that serotonin has a bidirectional function in modulating the innate attraction to ethanol and delineate a basic principle for how random behavior is switched into targeted approach behavior.
Serotonin in Animal Cognition and Behavior
- Biology, PsychologyInternational journal of molecular sciences
- 2020
The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior.
References
SHOWING 1-10 OF 36 REFERENCES
Y1 receptors regulate aggressive behavior by modulating serotonin pathways.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 2004
The results suggest that NPY acting through Y1 receptors regulates the 5-HT system, thereby coordinately linking physiological survival mechanisms such as food intake with enabling territorial aggressive behavior.
Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2005
A Drosophila signaling system, comprising neurons expressing neuropeptide F and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation is identified, providing the molecular and neural basis for the strikingly similar alcohol-responsive behaviors between flies and mammals.
Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila
- BiologyProceedings of the National Academy of Sciences
- 2006
It is proposed that NPF also plays a role in clock-controlled sexual dimorphism in adult Drosophila, and is under dual regulation by circadian and sex-determining factors.
Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster
- Biology, PsychologyCurrent Biology
- 2000
A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A
- Biology, PsychologyCurrent Biology
- 2006
From genes to aggressive behavior: the role of serotonergic system.
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 2006
This paper concentrates on the involvement of protein elements in the brain neurotransmitter serotonin (5-HT) system in the genetic control of aggressive behavior and provides converging lines of evidence that brain 5-HT contributes to a critical mechanism underlying genetically defined individual differences in aggressiveness.
Neuropeptide y: role in emotion and alcohol dependence.
- PsychologyCNS & neurological disorders drug targets
- 2006
The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined.
Drosophila as a new model organism for the neurobiology of aggression?
- Biology, PsychologyThe Journal of experimental biology
- 2002
Drosophila, with its advanced set of molecular tools and its behavioural richness, has the potential to develop into a new model organism for the study of the neurobiology of aggression.
The spectrum of behaviors influenced by serotonin
- Psychology, BiologyBiological Psychiatry
- 1998
Regulation of aversion to noxious food by Drosophila neuropeptide Y– and insulin-like systems
- BiologyNature Neuroscience
- 2005
The results suggest that the coordinated activities of the conserved NPY- and insulin-like receptor signaling systems are essential for the dynamic regulation of noxious food intake according to the animal's energy state.