Serotonin and impulsive aggression

@article{Coccaro2015SerotoninAI,
  title={Serotonin and impulsive aggression},
  author={Emil F. Coccaro and Jennifer R. Fanning and K. Luan Phan and Royce J. Lee},
  journal={CNS Spectrums},
  year={2015},
  volume={20},
  pages={295 - 302}
}
Aggression is a behavior with evolutionary origins, but is often both destructive and maladaptive in today’s society. Research over the past several decades has confirmed the involvement of neurotransmitter function in aggressive behavior. This research has centered around the “serotonin hypothesis.” As this literature continues to grow, guided by pre-clinical research and aided by the application of increasingly sophisticated neuroimaging methodology, a more complex picture has emerged. As… 
View on Cambridge Press
cambridge.org
98 Citations
Highly Influential Citations
3
Background Citations
33
Methods Citations
1
Results Citations
2

98 Citations

Translational Medicine Strategies for Drug Development for Impulsive Aggression

Maladaptive Aggression: With a Focus on Impulsive Aggression in Children and Adolescents

IA is a treatable form of maladaptive aggression that is distinct from other aggression subtypes that can serve as an important construct in clinical practice and has considerable potential to advance research.

Subtypes of aggression in intermittent explosive disorder.

Neural Foundations of Mood-Induced Impulsivity and Impulsive Aggression in Schizophrenia

Current neuroimaging findings regarding urgency and its relation to impulsive aggression in schizophrenia and potential relationships between urgency and emotional regulation are discussed, along with potential treatments for impulsive aggressors that could be developed via a consideration of the urgency construct.

The role of monoamine oxidase A in aggression: Current translational developments and future challenges

Neurobiology of Impulsivity and Aggression as Substrates of Suicidal Behavior: A Narrative Focus on the Involvement of Serum Lipids

This narrative review aimed to address and synthesize the literature regarding the involvement of lipids in the neurobiology of suicidal behavior and its underlying psychological substrates, impulsivity and aggression, and develop potential interventions to disrupt the pathogenesis of behavioral phenotypes of suicide.

Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine

A better understanding of the association between regional 5-HTT availability and state aggression, and the involvement of VST 5- HTT with trait aggression, is found, and with the anti-aggressive effects of fluoxetine is found.

Antipsychotics for aggression in adults: A meta-analysis

The role of central serotonin in impulsivity, compulsivity, and decision-making: comparative studies in experimental animals and humans

Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals

The first-ever postmortem analysis of serotonergic markers in the orbitofrontal cortex of male subjects with ASB documented a significant increase in 5-HT2A receptor levels in the ASB + SUD group compared to SUD-only controls, which point to this molecule as a potential target for ASB treatment.
...

References

SHOWING 1-10 OF 78 REFERENCES

The neurochemistry of human aggression.

Aggression, suicide, and serotonin: relationships to CSF amine metabolites.

The life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder were examined, and Histories of aggressive behaviors and of suicide attempts were significantly associated with each other.

Increased Serotonin 2A Receptor Availability in the Orbitofrontal Cortex of Physically Aggressive Personality Disordered Patients

Aggression, suicidality, and serotonin.

Data are discussed in the context of a proposed model for the pathophysiology of a postulated "low serotonin syndrome" in patients with unipolar depression and personality disorders and low concentrations of the major serotonin metabolite 5-hydroxyindoleacetic acid in the cerebrospinal fluid.

Serotonin and impulsive/aggressive behavior in cocaine dependent subjects

Revisiting the serotonin-aggression relation in humans: a meta-analysis.

The evidence for and against the serotonin deficiency hypothesis of human aggression across 4 methods of assessing serotonin is evaluated, and 4 possible explanations for the pattern of findings are discussed: unreliable measures, ambient correlational noise, an unidentified higher order interaction, and a selective serotonergic effect.

Serotonin Augmentation Reduces Response to Attack in Aggressive Individuals

As predicted, aggressive responding after provocation was attenuated by augmentation of serotonin in individuals with a pronounced history of aggression.

Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression

Changes in Brodmann areas 11 and 12 in the orbito-frontal cortex are consistent with a normalizing effect of fluoxetine on prefrontal cortex metabolism in impulsive aggressive disorder.

Aggression, Suicidality, and Intermittent Explosive Disorder: Serotonergic Correlates in Personality Disorder and Healthy Control Subjects

Physiologic responses to 5-HT stimulation are reduced as a function of aggression (but not generalized impulsivity) in human subjects and for subjects with a diagnosis of IED by research criteria, which have particular relevance to the notion of impulsive aggression and the biological validity of IIED.

Serotonin function and antiaggressive response to fluoxetine: A pilot study

...