Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine.

@article{Ellis2013SerotoninAC,
  title={Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine.},
  author={Melina Ellis and Jordan D. Chambers and Rachel M. Gwynne and Joel C Bornstein},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={304 8},
  pages={G749-61}
}
Segmentation is an important process in nutrient mixing and absorption; however, the mechanisms underlying this motility pattern are poorly understood. Segmentation can be induced by luminal perfusion of fatty acid in guinea pig small intestine in vitro and mimicked by the serotonin (5-HT) reuptake inhibitor fluoxetine (300 nM) and by cholecystokinin (CCK). Serotonergic and CCK-related mechanisms underlying nutrient-induced segmentation were investigated using selective 5-HT and CCK receptor… CONTINUE READING

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