Serotonin and brain function: a tale of two receptors

@inproceedings{CarhartHarris2017SerotoninAB,
  title={Serotonin and brain function: a tale of two receptors},
  author={R. Carhart-Harris and D. J. Nutt},
  booktitle={Journal of psychopharmacology},
  year={2017}
}
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-HT1A and 5-HT2A receptors. We propose that passive coping (i.e… CONTINUE READING

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