Serotonin and aversive Pavlovian control of instrumental behavior in humans.

  title={Serotonin and aversive Pavlovian control of instrumental behavior in humans.},
  author={Dirk E M Geurts and Quentin J M Huys and Hanneke den Ouden and Roshan Cools},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 48},
Adaptive decision-making involves interaction between systems regulating Pavlovian and instrumental control of behavior. Here we investigate in humans the role of serotonin in such Pavlovian-instrumental transfer in both the aversive and the appetitive domain using acute tryptophan depletion, known to lower central serotonin levels. Acute tryptophan depletion attenuated the inhibiting effect of aversive Pavlovian cues on instrumental behavior, while leaving unaltered the activating effect of… CONTINUE READING

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