Serotonin and apoptosis: studies on rat lymphocytes.


OBJECTIVE The apoptogenic potential of serotonin (5-hydroxytryptamine) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. METHODS Apoptosis was measured by morphologic criteria and flow cytometry. RESULTS In both assays, serotonin, at a concentration producing half-maximal inhibition of… (More)


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