Serotonin and Norepinephrine Reuptake Inhibition and Eating Behavior

@article{Hainer2006SerotoninAN,
  title={Serotonin and Norepinephrine Reuptake Inhibition and Eating Behavior},
  author={Vojtěch Hainer and Karolina Kabrnova and Bashar Aldhoon and Marie Kunesov{\'a} and Martin Wagenknecht},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1083}
}
Abstract:  Brain neurotransmitters, serotonin and norepinephrine, play an important role in the central nervous control of energy balance and are involved in symptomatology related to both obesity and depression. Therefore both serotonin and norepinephrine neural pathways have been paid a special attention as targets for the antiobesity drugs, antidepressants, and drugs used in the treatment of eating disorders. Selective serotonin reuptake inhibitors (SSRI) have been used in the treatment of… 
Dopamine and binge eating behaviors
TLDR
The data reviewed here support a role for dopamine in perpetuating the compulsive feeding patterns of BN and BED and it is proposed that sustained stimulation of the dopamine systems by bingeing promoted by preexisting conditions results in progressive impairments of dopamine signaling.
Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.
TLDR
Physiological inhibition of serotonin synthesis or signaling in key metabolic tissues are potential drug targets for obesity and non-alcoholic fatty liver disease and peripheral serotonin acts as an endocrine factor to promote the efficient storage of energy by upregulating lipid anabolism.
Association of central serotonin transporter availability and body mass index in healthy Europeans
TLDR
The data are in agreement with previous PET findings of an altered central serotonergic tone depending on BMI, as a probable pathophysiologic mechanism in obesity, and should encourage further clinical studies in obesity targeting theserotonergic system.
Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women.
TLDR
It is concluded that combined administration of fluoxetine and melatonin was useful option to treat mood, sleep and appetite disorders in postmenopausal women.
Central noradrenaline transporter availability in highly obese, non-depressed individuals
TLDR
Preliminary secondary findings of distinct regional and associative patterns warrant further investigation, and no significant differences in binding potential (BPND) values between obese and non-obese individuals in the investigated brain regions are found.
Serotonin-induced decrease of intracellular Ca2+ release in platelets of bulimic patients normalizes during treatment
TLDR
5-HT-induced Ca2+ release was significantly decreased in bulimic patients upon admission and normalized during inpatient treatment, providing further evidence that altered 5-HT2 receptor functioning is involved in the pathophysiological underpinnings in BN.
Current concepts on Eating Disorders , Etiology and Treatment
Anorexia nervosa (AN), bulimia nervosa (BN) and obesity are eating disorders (ED) are considered to be mental illness, while other contends ED is symptoms of starvation. ED is prevalent worldwide
Current concepts on Eating Disorders, Etiology and Treatment
TLDR
Eating disorders are considered to be mental illness, while other contends ED is symptoms of starvation, and prevention to aim a healthy development before the occurrence of ED, on-line program provides avenues for prevention.
Hunger and disinhibition but not cognitive restraint are associated with central norepinephrine transporter availability
TLDR
Initial data provide in vivo imaging support for the involvement of the central NE system in maladaptive eating behaviors such as susceptibility to hunger.
BDNF Level in the Rat Prefrontal Cortex Increases Following Chronic but Not Acute Treatment with Duloxetine, a Dual Acting Inhibitor of Noradrenaline and Serotonin Re-uptake
TLDR
It is shown that the mature, but not the precursor, form of BDNF was significantly increased in the prefrontal cortex of rats treated for 14 days with Duloxetine at 30 mg/kg/day.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 87 REFERENCES
Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa
TLDR
Elevated serotonin activity is consistent with behaviors found after recovery from AN, such as obsessionality with symmetry and exactness, harm avoidance, perfectionism, and behavioral over control, which raise the possibility that a disturbance of serotonin activity may create a vulnerability for the expression of a cluster of symptoms that are common to both AN and BN.
The role of antidepressants in the treatment of abdominal obesity.
TLDR
Preliminary results indicate that serotoninergic agents decrease abdominal fat mass with improvements in related risk factors and may interrupt the vicious circle of a hyperactive HPA axis leading to increasing abdominal obesity and endocrine perturbations that, in turn, leads to progressive accumulation of abdominal fat.
Use of sibutramine an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: A placebo-controlled study
TLDR
The findings suggest sibutramine is an effective medication in the treatment of binge-eating disorders and is well tolerated, and addresses the 3 main goals in the Treatment of Binge-eating disorder: reducing the frequency of binge eating, promoting and maintaining weight loss, and treating the comorbid psychiatric conditions.
Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity.
The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation
Obesity and depression: same disease, different names?
TLDR
The notion that obesity and depression may represent different manifestations of the same disease process - Janus faces of the modern society is proposed.
Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity.
The metabolic syndrome, recognized by the co-occurrence of general or abdominal obesity, hypertension, dyslipidemia, insulin resistance, and dysglycemia, appears to involve disturbances in
Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies
TLDR
Emerging data point to a dysregulation of serotonin pathways in cortical and limbic structures that may be related to anxiety, behavioral inhibition, and body image distortions in Anorexia and bulimia nervosa.
Pharmacological approaches in the treatment of binge eating disorder.
TLDR
Antidepressants, anti-obesity agents, and anticonvulsants have been shown to significantly reduce binge eating behavior and body weight in BED associated with obesity.
Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine.
TLDR
The combination of these two selective monoamine reuptake inhibitors profoundly enhances thermogenesis, demonstrating a synergistic interaction of 5-HT and noradrenaline neurotransmission in the regulation of energy expenditure.
Hypothalamic-pituitary-adrenal axis in the night eating syndrome.
TLDR
Results showed that disturbances in the hypothalamic-pituitary-adrenal axis with an attenuated ACTH and cortisol response to CRH were found in subjects with night-eating syndrome.
...
1
2
3
4
5
...