Serotonin and Hallucinogens

@article{Aghajanian1999SerotoninAH,
  title={Serotonin and Hallucinogens},
  author={GK Aghajanian and GJ Marek},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={21},
  pages={16S-23S}
}
This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950 s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. The noradrenergic… CONTINUE READING
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