Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.

Abstract

The aim of this study was to demonstrate that 5-HT activates electrolyte transport directly via 5-HT2A receptor in rat colonic crypt cells. Patch-clamp whole cell recording was performed in isolated crypts to measure the 5-HT-induced changes in electrogenic K+ and Cl- currents. Superfusing 5-HT (10 microM) in the bath solution increased both K+ and Cl… (More)

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