Serotonin activates angiogenic phosphorylation signaling in human endothelial cells.

@article{Zamani2012SerotoninAA,
  title={Serotonin activates angiogenic phosphorylation signaling in human endothelial cells.},
  author={Ali Zamani and Zhican Qu},
  journal={FEBS letters},
  year={2012},
  volume={586 16},
  pages={2360-5}
}
Serotonin, a known neurotransmitter, also functions as an angiokine to promote angiogenesis. The majority of serotonin in the human body is stored in platelets, and platelet aggregation leads to significant release of serotonin in thrombotic tumor environment. We have investigated serotonin signaling in human endothelial cells. Through G-protein-coupled receptors, serotonin at physiologically relevant concentrations activated Src/PI3K/AKT/mTOR/p70S6K phosphorylation signaling, and this… CONTINUE READING
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