Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.

  title={Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.},
  author={Erick H. Turner and Jennifer M. Loftis and Aaron D. Blackwell},
  journal={Pharmacology \& therapeutics},
  volume={109 3},

5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

  • M. Maffei
  • Biology, Chemistry
    International journal of molecular sciences
  • 2020
The physiological role of 5-HTP in the treatment of depression, anxiety, panic, sleep disorders, obesity, myoclonus and serotonin syndrome are discussed and the occurrence of toxic impurities present in tryptophan and 5- HTP preparations are discussed.

Mechanism of acute tryptophan depletion: is it only serotonin?

It is suggested that caution is required when interpreting ATD effects in terms of a selective serotonergic effect, as the potential of alternative mechanisms and possible confounding factors should be taken into account.

Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders

The data which support TPH2 as novel drug target are summarized and strategies for its pharmacological exploitation are discussed.

The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque

B baseline central serotonergic functioning may underlie and predict variation in serotonin’s effects on cognitive operation, which may help inform serotonin's role in psychopathology and help clinicians predict howserotonergic interventions will influence pathologies.

Enhanced production of 5-hydroxytryptophan through the regulation of L-tryptophan biosynthetic pathway

The 5-HTP production was increased to 1.61 g/L in the shaking flasks, which was 24% improvement comparing to the original producing strain, while the content of residual L-trp was successfully reduced from 1.66 to 0.2 G/L, which is beneficial for the downstream separation and purification.

Oral 5-Hydroxytryptophan (5-HTP) Does not Affect Grooved Pegboard Test Performance

If oral administration of 150 mg of 5-HTP disrupts fine motor control, as measured by the Grooved Pegboard Test, is clarified by determining if oral treatment with 5- HTP causes motor or cognitive impairment.

Boosting serotonin in the brain: is it time to revamp the treatment of depression?

A recently discovered isoform, TPH2, is responsible for serotonin biosynthesis in the brain, and learning how to activate this enzyme may lead to a new, more selective generation of antidepressants, able to regulate the levels of serotonin in thebrain with fewer side effects.

Serotonin and Blood Pressure Regulation

This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure, with a focus on the autonomic nervous system, and compares the change in blood pressure produced in different species by short- and long-term administration of5-HT or selective serotonin receptor agonists.



5-Hydroxytryptophan: a clinically-effective serotonin precursor.

  • T. Birdsall
  • Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 1998
Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia.


Safety of 5-hydroxy-L-tryptophan.

The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression.

The mechanisms by which administration of interferon-alpha induces neuropsychiatric side effects, such as depressive symptoms and changes in cognitive function, are not clear as yet. Direct influence

Are Tryptophan and 5-Hydroxytryptophan Effective Treatments for Depression? A Meta-Analysis∗

These studies suggest 5-HT and L-tryptophan are better than placebo at alleviating depression, but the small size of the studies, and the large number of inadmissible, poorly executed studies, casts doubt on the result from potential publication bias and suggests that they are insufficiently evaluated to assess their effectiveness.

The indoleamine hypothesis of depression: an overview and pilot study.

The clinical and biochemical data on six patients with depression treated with L-5-HTP in a nonrandom, double-blind protocol suggest that in a postulated subgroup of depressed patients with pituitary adrenal hyperactivity and evidence of serotonin deficiency, L5- HTP deserves a further trial as an experimental treatment.

5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects.

A review of studies suggests that 5-HTP possesses antidepressant properties, and highlights adverse effects associated with its administration to depressed patients, neurologic subjects, and normal individuals.

L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression.

Gastrointestinal side effects proved to be dose-dependent and occurred more frequently in patients receiving L-5-HTP alone, whereas psychopathological side effects have mainly been reported in patients Receiving L- 5- HTP in combination with a peripheral decarboxylase inhibitor.