Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.

@article{Turner2006SerotoninAL,
  title={Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.},
  author={Erick H. Turner and Jennifer M Loftis and Aaron D Blackwell},
  journal={Pharmacology & therapeutics},
  year={2006},
  volume={109 3},
  pages={
          325-38
        }
}
This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Factors affecting each of these… CONTINUE READING
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