Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

@article{Hariri2002SerotoninTG,
  title={Serotonin Transporter Genetic Variation and the Response of the Human Amygdala},
  author={Ahmad R. Hariri and Venkata S. Mattay and Alessandro Tessitore and Bhaskar S. Kolachana and Francesco Fera and David Goldman and Michael Egan and Daniel R. Weinberger},
  journal={Science},
  year={2002},
  volume={297},
  pages={400 - 403}
}
A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. We… Expand

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