Serotonin Transporter Gene Promoter Polymorphism and Alexithymia

  title={Serotonin Transporter Gene Promoter Polymorphism and Alexithymia},
  author={Michiko Kano and Tomoko Mizuno and Yuko Kawano and Masashi Aoki and Motoyori Kanazawa and Shin Fukudo},
  pages={76 - 82}
Background: Recent neurobiological studies have reported that alexithymia may result from altered brain function related to emotional processing. Serotonin (5-hydroxytryptamine, 5-HT) has been shown to regulate central nervous system development associated with psychological processing. We investigated the possibility that polymorphism of the 5-HT transporter-linked promoter region (5-HTTLPR) is associated with alexithymia. Methods: This study included 304 healthy Japanese volunteers (148 males… 

Figures and Tables from this paper

Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation

The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder

The results showed that both PD patients and normal controls with the BDNF Met/Met genotype had significantly higher total and difficulty describing feelings(DDF) subdimension scores on the TAS-20 than those with the Val/Val genotype.

IL-18 Serum Levels and Variants of the Serotonin Transporter Gene Are Related to Awareness of Emotions in Healthy Subjects: A Preliminary Study

Results indicate a possible novel interaction between IL-18 and the serotoninergic system to mediate emotional unawareness, suggesting putative biological predictors of emotional dysregulation, which in turn can act as a risk factor for a variety of medical conditions in susceptible subjects.

Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C

Patients with a higher level of alexithymia and the HTR1A-G gene variant are more vulnerable to experiencing IFN-induced depressive symptoms.

Differential Influence of 5-HTTLPR - Polymorphism and COMT Val158Met - Polymorphism on Emotion Perception and Regulation in Healthy Women

Results indicate that genetic variants of the COMT and 5HTTLPR genes are differentially associated with specific measures of the self-estimated effectiveness of an individual’s emotion perception and regulation in the intra-personal domain.

5-HTTLPR and gender differences in affective disorders: A systematic review.

The role of the serotonin transporter gene, brain structure and family environment in the emergence of depression during adolescence

This thesis aims to enhance current understanding of this interaction by considering how two different dimensions of environmental experience (threat versus deprivation) might interact with the serotonin transporter gene during adolescence, while also investigating potential underlying neurobiological mechanisms.



Association between the Catechol O-Methyltransferase Val108/158Met Polymorphism and Alexithymia

There was no significant relationship between the 5-HTTLPR genotype and TAS-20 scores, which indicates a possible association between the COMT Val108/158Met gene polymorphism and alexithymia.

Serotonin transporter gene promoter polymorphism and somatoform symptoms.

Somatic symptoms may be associated with a functional polymorphism in the promoter region of the serotonin transporter gene, a limiting factor of the serotonergic neuronal system.

Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

Genetically driven variation in the response of brain regions underlying human emotional behavior is demonstrated and differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.

The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention.

The unexpected finding that ss volunteers showed improved memory and attention relative to ll volunteers suggests a possible evolutionary advantage to possession of the s allele, which may offset the disadvantage of vulnerability to depression following stressful life events.

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting

Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder

The results suggest that the VNTR itself or another unknown functional polymorphism which would be in linkage disequilibrium to the VnTR has an effect on susceptibility to bipolar disorder.

Anxious Behavior and Fenfluramine-Induced Prolactin Secretion in Young Rhesus Macaques with Different Alleles of the Serotonin Reuptake Transporter Polymorphism (5HTTLPR)

Genotyped 128 infant and juvenile monkeys for the 5HTTLPR and tested for behavioral response in four testing paradigms designed to elicit fearful-anxious behaviors, indicating greater anxiety in the s/s monkeys for distinct facets of anxious behavior, which are independent of a global neurohormonal challenge test.

Association between serotonin transporter gene polymorphism and chronic fatigue syndrome.