Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

  title={Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex},
  author={Lei Xing and Nereo Kalebic and Takashi Namba and Samir Vaid and Pauline Wimberger and Wieland B. Huttner},
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility
The data are consistent with the notion that neocortex expansion by ARHGAP11B, a gene implicated in human evolution, underlies some of the altered neurobehavioural features observed in the transgenic mice, such as the increased memory flexibility, a neocortex‐associated trait, with implications for the increase in cognitive abilities during human evolution.
Glutaminolysis and the Control of Neural Progenitors in Neocortical Development and Evolution.
  • Vasiliki Gkini, T. Namba
  • Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2022
The role of NPC metabolism in neocortical development, evolution, and neurodevelopmental disorders is discussed, providing a broader perspective on a newly emerging research field.
The Ferret as a Model System for Neocortex Development and Evolution
The molecular, cellular, and histological features that make the domesticated ferret a suitable animal model to study the physiological and pathological mechanisms for the development of an expanded neocortex are discussed and the features of neocortex development in the ferret are compared with those of other model organisms.
How neural stem cells contribute to neocortex development
Dissecting the differences between NPC types and differences among mammalian species is beneficial to further understand the development and the evolutionary expansion of the neocortex and may open up new therapeutic avenues for neurodevelopmental and psychiatric disorders.
Neural stem cells-from quiescence to differentiation and potential clinical uses
Understanding molecular mechanisms underlying neuronal differentiation is of great importance in elucidating pathological conditions of the brain and treating neurodegenerative disorders that until now have no efficient therapies.
The Effects of Environmental Adversities on Human Neocortical Neurogenesis Modeled in Brain Organoids
This review discusses how brain organoids have recently revealed commonalities and differences in the effects of environmental adversities on human neurogenesis, and highlights both the breakthroughs in understanding the molecular consequences of environmental exposures achieved using organoids as well as the on-going challenges in the field related to variability in protocols and a lack of benchmarking.
Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish
Life-long disruptive effects of FLX are reported on pathways associated with neuroendocrine signaling, stress response and the circadian rhythm, and all of which are implicated in the development of depressive disorders in humans.
microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1
Collectively, miR-140-3p might repress neuron pyroptosis to alleviate Sevo inhalation-induced POCD in rats via DNMT1/HTR2A/ERK/Nrf2 axis.
Is the Exposome Involved in Brain Disorders through the Serotoninergic System?
This review presents the available data that are contributing to the appreciation of the effects of the exposome on the serotoninergic system and their potential link with brain pathologies (neurodevelopmental, neurodegenerative, neurobehavioral disorders, and glioblastoma).
Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets
Recent findings regarding the mechanisms underlying the development and evolution of the mammalian cerebral cortex are summarized, mainly focusing on research using ferrets.


Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex
It is demonstrated that sustaining Pax6 expression selectively in BP-genic apical radial glia (aRG) and their BP progeny of embryonic mouse neocortex suffices to induce primate-like progenitor behaviour and imply that sustaining this Pax6 function in BPs could be a key aspect of SVZ enlargement and, consequently, the evolutionary expansion of the neocortex.
Integrin αvβ3 and thyroid hormones promote expansion of progenitors in embryonic neocortex
Convergence of ECM and thyroid hormones on integrin αvβ3 thus appears to be crucial for cortical progenitor proliferation and self-renewal, and hence for normal brain development and the evolutionary expansion of the neocortex.
Monoamine Oxidases Regulate Telencephalic Neural Progenitors in Late Embryonic and Early Postnatal Development
The results suggest that a MAO-dependent long-lasting alteration in the proliferation capacity of NSC occurs late in embryonic development and is mediated by serotonin, revealing novel roles for MAOs and serotonin in the regulation of IPC proliferation in the developing brain.
Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
Human-specific ARHGAP11B can elicit hallmarks of neocortical expansion in the developing ferret neocortex and exhibits increased neuron density in the upper cortical layers and expands in both the radial and tangential dimensions.
Serotonin Promotes the Survival of Cortical Glutamatergic Neuronsin Vitro
Results indicate that 5-HT does not exert its effects on dividing neuroepithelial cells in the developing cortex, but rather on postmitotic neurons.
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
This work analyzes the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity–based approach from developing mouse and human neocortex and identifies 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs, including ARHGAP11B, which has the highest degree of radialglia–specific expression.