Serotonin Modulates Sensitivity to Reward and Negative Feedback in a Probabilistic Reversal Learning Task in Rats

@article{Bari2010SerotoninMS,
  title={Serotonin Modulates Sensitivity to Reward and Negative Feedback in a Probabilistic Reversal Learning Task in Rats},
  author={Andrea Bari and David E. H. Theobald and Daniele Caprioli and A. C. Du Mar and Alex Aidoo-Micah and Jeffrey W. Dalley and Trevor W. Robbins},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1290-1301}
}
Depressed patients show cognitive deficits that may depend on an abnormal reaction to positive and negative feedback. The precise neurochemical mechanisms responsible for such cognitive abnormalities have not yet been clearly characterized, although serotoninergic dysfunction is frequently associated with depression. In three experiments described here, we investigated the effects of different manipulations of central serotonin (5-hydroxytryptamine, 5-HT) levels in rats performing a… CONTINUE READING
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