Corpus ID: 81581873

Serotonin-Induced Hypercontraction Through 5-Hydroxytryptamine 1B Receptors in Atherosclerotic Rabbit Coronary Arteries

@article{TatsuroIshida2001SerotoninInducedHT,
  title={Serotonin-Induced Hypercontraction Through 5-Hydroxytryptamine 1B Receptors in Atherosclerotic Rabbit Coronary Arteries},
  author={TatsuroIshida and SeinosukeKawashima and Ken-ichiHirata and TsuyoshiSakoda and YasushiShimokawa and YoichiMiwa and NobutakaInoue and TomomiUeyama and MasashiShiomi and HozukaAkita and MitsuhiroYokoyama},
  journal={Circulation},
  year={2001}
}
Background—Augmented vasoconstriction to serotonin (5-hydroxytryptamine [5-HT]) in atherosclerotic vessels plays a crucial role in the development of myocardial ischemia. We investigated mechanisms for serotonin-evoked hypercontraction in atherosclerotic rabbit coronary arteries. Methods and Results—Contractile responses to serotonergic agents of endothelium-denuded coronary arteries from control and Watanabe heritable hyperlipidemic rabbits (WHHL) were examined. WHHL coronary arteries… Expand
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