Serotonin-Dopamine Interactions in the Control of Conditioned Reinforcement and Motor Behavior

  title={Serotonin-Dopamine Interactions in the Control of Conditioned Reinforcement and Motor Behavior},
  author={Deanna M Sasaki-Adams and Ann E. Kelley},
These studies addressed the question of serotonin (5-HT)-dopamine (DA) interactions with regard to reward-related behavior and motor activity in rats. The first experiment evaluated the effect of chronic treatment with fluoxetine (7 mg/kg/day), a serotonin-selective reuptake inhibitor, and buproprion (15 mg/kg/day), a dopamine reuptake inhibitor, on responding for conditioned reinforcement (CR). Chronic fluoxetine, but not buproprion, enhanced CR responding, and also potentiated cocaine-induced… CONTINUE READING

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