Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus

@article{Hurley1999SerotoninDM,
  title={Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus},
  author={Laura M. Hurley and George D. Pollak},
  journal={The Journal of Neuroscience},
  year={1999},
  volume={19},
  pages={8071 - 8082}
}
  • L. HurleyG. Pollak
  • Published 15 September 1999
  • Biology, Psychology
  • The Journal of Neuroscience
Although almost all auditory brainstem nuclei receive serotonergic innervation, little is known about its effects on auditory neurons. We address this question by evaluating the effects of serotonin on sound-evoked activity of neurons in the inferior colliculus (IC) of Mexican free-tailed bats. Two types of auditory stimuli were used: tone bursts at the neuron’s best frequency and frequency-modulated (FM) sweeps with a variety of spectral and temporal structures. There were two main findings… 

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  • L. Hurley
  • Biology, Psychology
    Journal of neurophysiology
  • 2006
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Modulation of auditory brainstem responses by serotonin and specific serotonin receptors

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Serotonin 1B receptor modulates frequency response curves and spectral integration in the inferior colliculus by reducing GABAergic inhibition.

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The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs

Sound-by-sound electrical stimulation revealed fast and ear-specific auditory modulation that is potentially suited to shifts in auditory attention during sound segregation in the auditory scene.
...

References

SHOWING 1-10 OF 81 REFERENCES

Serotonin modulates auditory information processing in the cochlear nucleus of the rat

Medial superior olive in the free-tailed bat: response to pure tones and amplitude-modulated tones.

The response of the MSO in the free-tailed bat is created by a complex interaction of inhibition and excitation, and the data confirm an earlier speculation about this interdependence based on data accessed from a gerbil brain slice preparation.

Serotonin and Serotonin Receptors in the Central Auditory System

The present neuroanatomic and neurochemical findings support behavioral and neurophysiologic findings that the serotonergic system may modulate central auditory processing.

Serotonergic facilitation of quantal release at central inhibitory synapses

  • I. MintzH. Korn
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
Results indicate that 5-HT increases the efficacy of inhibitory synaptic transmission in the vertebrate CNS by a presynaptic action that acts presynaptically to increase the probability of evoked and spontaneous release of glycine.

Effects of serotonin on retinotectal-, corticotectal-, and glutamate-induced activity in the superior colliculus of the hamster.

It is demonstrated that 5-HT markedly depresses the visual responses of most superficial layer SC neurons and suggested further that much of this effect is mediated by presynaptic inhibition of retinotectal transmission.
...