Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus

  title={Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus},
  author={Laura M. Hurley and George D. Pollak},
  journal={The Journal of Neuroscience},
  pages={8071 - 8082}
  • L. HurleyG. Pollak
  • Published 15 September 1999
  • Biology, Psychology
  • The Journal of Neuroscience
Although almost all auditory brainstem nuclei receive serotonergic innervation, little is known about its effects on auditory neurons. We address this question by evaluating the effects of serotonin on sound-evoked activity of neurons in the inferior colliculus (IC) of Mexican free-tailed bats. Two types of auditory stimuli were used: tone bursts at the neuron’s best frequency and frequency-modulated (FM) sweeps with a variety of spectral and temporal structures. There were two main findings… 

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  • L. Hurley
  • Biology, Psychology
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  • 2006
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The response of the MSO in the free-tailed bat is created by a complex interaction of inhibition and excitation, and the data confirm an earlier speculation about this interdependence based on data accessed from a gerbil brain slice preparation.

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Serotonergic facilitation of quantal release at central inhibitory synapses

  • I. MintzH. Korn
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
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Effects of serotonin on retinotectal-, corticotectal-, and glutamate-induced activity in the superior colliculus of the hamster.

It is demonstrated that 5-HT markedly depresses the visual responses of most superficial layer SC neurons and suggested further that much of this effect is mediated by presynaptic inhibition of retinotectal transmission.