Serotonin Depletion Hampers Survival and Proliferation in Neurospheres Derived from Adult Neural Stem Cells

@article{Benninghoff2010SerotoninDH,
  title={Serotonin Depletion Hampers Survival and Proliferation in Neurospheres Derived from Adult Neural Stem Cells},
  author={Jens Benninghoff and Angela Pesenti Gritti and Matteo Rizzi and Giuseppe Lamorte and Robert J. Schloesser and Angelika Gertrud Schmitt and Stefanie Robel and Just Genius and Rainald Moessner and Peter Franz Riederer and Husseini K. Manji and Heinz Grunze and Dan Rujescu and Hans-J{\"u}rgen M{\"o}ller and Klaus-Peter Lesch and Angelo L. Vescovi},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={893-903}
}
Serotonin (5-HT) and the serotonergic system have recently been indicated as modulators of adult hippocampal neurogenesis. In this study, we evaluated the role of 5-HT on the functional features in neurospheres derived from adult neural stem cells (ANSC). We cultured neurospheres derived from mouse hippocampus in serum-free medium containing epidermal (EGF) and type-2 fibroblast growth factor (FGF2). Under these conditions ANSC expressed both isoforms of tryptophane-hydroxylase (TPH) and… CONTINUE READING
23 Citations
72 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Similar Papers

Loading similar papers…