Serotonin Augmentation Reduces Response to Attack in Aggressive Individuals

  title={Serotonin Augmentation Reduces Response to Attack in Aggressive Individuals},
  author={Mitchell E. Berman and Michael McCloskey and Jennifer R. Fanning and Julie A. Schumacher and Emil F. Coccaro},
  journal={Psychological Science},
  pages={714 - 720}
We tested the theory that central serotonin (5-hydroxytryptamine, or 5-HT) activity regulates aggression by modulating response to provocation. Eighty men and women (40 with and 40 without a history of aggression) were randomly assigned to receive either 40 mg of paroxetine (to acutely augment serotonergic activity) or a placebo, administered using double-blind procedures. Aggression was assessed during a competitive reaction time game with a fictitious opponent. Shocks were selected by the… 

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