Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons

@article{Tajiri2012Serotonin5R,
  title={Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons},
  author={Minako Tajiri and Atsuko Hayata-Takano and Kaoru Seiriki and Katsuya Ogata and Keisuke Hazama and Norihito Shintani and Akemichi Baba and Hitoshi Hashimoto},
  journal={Journal of Molecular Neuroscience},
  year={2012},
  volume={48},
  pages={473-481}
}
The serotonin 5-HT7 receptor has been linked to various psychiatric disorders, including schizophrenia, anxiety and depression, and is antagonized by antipsychotics such as risperidone, clozapine and lurasidone. In this study, we examined whether inhibiting the 5-HT7 receptor could reverse behavioral abnormalities in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP), an experimental mouse model for psychiatric disorders such as schizophrenia. The selective 5-HT7 antagonist… CONTINUE READING

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