Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors.

@article{LpezGimnez2002Serotonin5H,
  title={Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors.},
  author={Juan Francisco L{\'o}pez-Gim{\'e}nez and Laurence H. Tecott and Jos{\`e} Maria Palacios and Guadalupe Mengod and Maria Teresa Vilar{\'o}},
  journal={Journal of neuroscience research},
  year={2002},
  volume={67 1},
  pages={69-85}
}
Quantitative receptor autoradiography was used to study possible alterations of the densities of multiple serotonin (5-HT) receptor subtypes and of serotonin transporter in the brain of 5-HT(2C) receptor knockout mice. The radioligands employed were [(3)H]citalopram, [(3)H]WAY100,635, [(3)H]8-OH-DPAT, [(3)H]GR125743, [(3)H]sumatriptan, [(3)H]MDL100,907, [(125)I](+/-)DOI, [(3)H]mesulergine, [(3)H]5-HT, [(3)H]GR113808, and [(3)H]5-CT. As expected, radioligands that label 5-HT(2C) receptors showed… CONTINUE READING

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