Serotonin 5-HT(3) receptor mediation of pain and anti-nociception: implications for clinical therapeutics.

@article{Giordano2004Serotonin5R,
  title={Serotonin 5-HT(3) receptor mediation of pain and anti-nociception: implications for clinical therapeutics.},
  author={James Giordano and Thomas D Schultea},
  journal={Pain physician},
  year={2004},
  volume={7 1},
  pages={141-7}
}
The involvement of the serotonergic system in pain and anti-nociception has long been recognized. Throughout the nervous system, serotonin (5-HT) exerts effects through heterogeneous populations of receptors that have recently been categorized into distinct "families" based upon their molecular properties. Of these, the 5-HT(3) receptor is distinct in that it is inotropic, mediating a sodium current, and thus is exclusively excitatory, irrespective of the tissue(s) in which it is localized… CONTINUE READING

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