Serotonin 5‐HT2A Receptor Activation Inhibits Cytokine‐stimulated Inducible Nitric Oxide Synthase in C6 Glioma Cells a

@article{Miller1998Serotonin5R,
  title={Serotonin 5‐HT2A Receptor Activation Inhibits Cytokine‐stimulated Inducible Nitric Oxide Synthase in C6 Glioma Cells a},
  author={Keith J. Miller and Hugo Gonz{\'a}lez},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={861}
}
ABSTRACT: C6‐glioma cells endogenously express both 5‐HT2A receptors and inducible nitric oxide synthase (iNOS). iNOS can be induced by transcriptional activation to produce nitric oxide (NO) in response to a challenge with the pro‐inflammatory cytokines TNF‐α and IFN‐γ. Experiments were conducted to determine whether 5‐HT2A receptor activation could modify the production of NO in response to the inducing agents. 1 μM DOI produced a dose‐dependent inhibition of the cytokine‐inducted nitrite… 
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MOLECULAR MECHANISMS REGULATING iNOS EXPRESSION IN VARIOUS CELL TYPES
  • K. M. Rao
  • Biology
    Journal of toxicology and environmental health. Part B, Critical reviews
  • 2000
TLDR
A comprehensive table of cell types that produce NO together with the effects of agents used to study iNOS regulation, as a ready reference for the investigators in the field, and to summarize recent observations dealing with iNos signal transduction mechanisms are presented.
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The biological role of nitric oxide in the central nervous system and gliomas and its current and future possibilities in neuro-oncology are discussed.
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Data suggest that regulation of fatigue and depressive-like moods after episodes of systemic inflammation may be regulated by changes in 5-HT receptor expression, rather than by levels of enzyme activity or cytokine expression in the CNS.
Functions of serotonin in hypoxic pulmonary vascular remodeling
TLDR
The contribution of serotonin, its receptors and transporter in lung hypoxic responses is discussed and why expression of pulmonary vascular remodeling factors is not modified in hypoxic 5-HT2B receptor mutant mice is explained.
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