Serotonin 5‐HT2A Receptor Activation Inhibits Cytokine‐stimulated Inducible Nitric Oxide Synthase in C6 Glioma Cells a

@article{Miller1998Serotonin5R,
  title={Serotonin 5‐HT2A Receptor Activation Inhibits Cytokine‐stimulated Inducible Nitric Oxide Synthase in C6 Glioma Cells a},
  author={Keith J. Miller and Hugo Gonz{\'a}lez},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={861}
}
ABSTRACT: C6‐glioma cells endogenously express both 5‐HT2A receptors and inducible nitric oxide synthase (iNOS). iNOS can be induced by transcriptional activation to produce nitric oxide (NO) in response to a challenge with the pro‐inflammatory cytokines TNF‐α and IFN‐γ. Experiments were conducted to determine whether 5‐HT2A receptor activation could modify the production of NO in response to the inducing agents. 1 μM DOI produced a dose‐dependent inhibition of the cytokine‐inducted nitrite… 
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Angiotensin II‐Induced Decrease in Expression of Inducible Nitric Oxide Synthase in Rat Astroglial Cultures
TLDR
Data indicate a role for PKC in the inhibitory actions of Ang II on iNOS expression in cultured astroglia and the reduction of lipopolysaccharide‐induced nitrite accumulation by Ang II was attenuated by the selective PKC inhibitor chelerythrine.
Inducible nitric oxide synthase in P11 cells: expression in the presence of interferon-gamma, lipopolysaccharide, and modified serum.
Serotonin 5-Hydroxytryptamine2A Receptor Activation Suppresses Tumor Necrosis Factor-α-Induced Inflammation with Extraordinary Potency
TLDR
The results indicate that activation of 5-HT2A receptors represents a novel, and extraordinarily potent, potential therapeutic avenue for the treatment of disorders involving TNF-α-mediated inflammation.
Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors.
TLDR
The findings suggest that the inhibition of TNF-alpha production by 5- HT involves the participation of the 5-HT(2A) receptor subtypes in PBMC, and support a role of 5-ht in inflammation through its effect on cytokine production inPBMC.
MOLECULAR MECHANISMS REGULATING iNOS EXPRESSION IN VARIOUS CELL TYPES
  • K. M. Rao
  • Biology
    Journal of toxicology and environmental health. Part B, Critical reviews
  • 2000
TLDR
A comprehensive table of cell types that produce NO together with the effects of agents used to study iNOS regulation, as a ready reference for the investigators in the field, and to summarize recent observations dealing with iNos signal transduction mechanisms are presented.
The effect of chronic antipsychotic drug administration on nitric oxide synthase activity and gene expression in rat penile tissues
Nitric oxide and glioma: a target for novel therapy?
TLDR
The biological role of nitric oxide in the central nervous system and gliomas and its current and future possibilities in neuro-oncology are discussed.
A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT2A Receptor Expression in Mice
TLDR
Data suggest that regulation of fatigue and depressive-like moods after episodes of systemic inflammation may be regulated by changes in 5-HT receptor expression, rather than by levels of enzyme activity or cytokine expression in the CNS.
Functions of serotonin in hypoxic pulmonary vascular remodeling
TLDR
The contribution of serotonin, its receptors and transporter in lung hypoxic responses is discussed and why expression of pulmonary vascular remodeling factors is not modified in hypoxic 5-HT2B receptor mutant mice is explained.
Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat
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References

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