Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus.

@article{Reisoli2010Serotonin2R,
  title={Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus.},
  author={Elisa Reisoli and Stefania De Lucchini and Irma Nardi and Michela Ori},
  journal={Development},
  year={2010},
  volume={137 17},
  pages={2927-37}
}
Serotonin (5-HT) is a neuromodulator that plays many different roles in adult and embryonic life. Among the 5-HT receptors, 5-HT2B is one of the key mediators of 5-HT functions during development. We used Xenopus laevis as a model system to further investigate the role of 5-HT2B in embryogenesis, focusing on craniofacial development. By means of gene gain- and loss-of-function approaches and tissue transplantation assays, we demonstrated that 5-HT2B modulates, in a cell-autonomous manner… CONTINUE READING

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