Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.

@article{Marcusson1984Serotonin2BS,
  title={Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.},
  author={Jan Marcusson and David G A Morgan and Bengt Winblad and Caleb E. Finch},
  journal={Brain research},
  year={1984},
  volume={311 1},
  pages={51-6}
}
Serotonin (S-2) binding sites were characterized in human frontal cortex and hippocampus throughout the lifespan. We found that the S-2 binding sites (labeled by [3H]spiperone and displaced by ketanserin) consisted of two subtypes (S-2A and S-2B) which are discriminated by competition with methysergide. The total S-2 sites in frontal cortex had a Bmax of 360 fmol/mg protein, which is approximately twice that of the hippocampus (160 fmol/mg protein). The density of total S-2 sites decreased with… CONTINUE READING