Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine

  title={Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine},
  author={P. H. Wu and Nataly Gurevich and Peter L. Carlen},
  journal={Neuroscience Letters},
Effects of 5-hydroxytryptamine on the firing rates of neurons of the lateral vestibular nucleus in the rat
It is demonstrated that 5-HT modifies the responsiveness of vestibular neurons and suggest that at least two mechanisms and maybe two types of receptors are activated by 5- HT in this nucleus.
5‐HT1A Receptors and 5‐HT1A‐Mediated Responses: Effect of Treatments That Modify Serotonergic Neurotransmission
Repeated treatment of rats with the lipophilic partial PZ agonist clenbuterol reduces the density of P-adrenoceptors throughout the central nervous system (CNS), and it is found that intraventricular administration of the full P- adrenoceptor agonist, isoproterenol, decreased thedensity of BARs, particularly the P2 subtype, in many areas of brain.
Actions of 5‐HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats
It is concluded that hippocampal synaptic transmission is highly sensitive to the agonist and antagonist properties of 5‐HT1 ligands in the alert rat.
The biophysical and pharmacological properties of presumptive serotonergic neurones recorded intracellularly from the dorsal raphe nucleus in the in vitro slice preparation
The selective 5-HT^ agonists 8hydroxy-2-(di-n-propylamino)teralin (8-OHDPAT), dipropylcarboxamidotryptamine (DP-5-CT) and the novel anxiolytic buspirone caused a marked longlasting hyperpolarisation with an associated decrease in Rm and r at concentrations lower than required for an equivalent response to 5- HT.


5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.
The effect of antidepressants was agonist-specific in that neither alpha-1 adrenoceptor nor muscarinic receptor stimulation were altered by acute or chronic treatment and only the high-affinity component of the dose-response curve was sensitive to antagonists.
Multiple serotonin receptors and their physiological significance.
Influences of antidepressants on 5-HT2 receptors may provide a useful predictive test for antidepressant drug action.
Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin
The mechanism of serotonin action on CA1 cells in rat hippocampal slices is clarified and three distinct actions of serotonin (or 5-HT) on identified K-conductances in these cells are described.
The action of serotonin in the rat hippocampal slice preparation.
  • M. Segal
  • Biology
    The Journal of physiology
  • 1980
These experiments indicate that 5‐HT produces its effects in the rat hippocampus by activating K+ channels and is true post‐synaptic responses and are not indirect effects since they are present in a Ca2‐deficient Mg2+‐enriched medium which blocks synaptic transmission.
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons.
It is concluded that AHP is probably activated by Ca2+ influx, and is distinct from the IPSP, which indicates that the AHP may be produced by a Ca2-activated K+ current.