Serotonin (5-Hydroxytryptamine), a Novel Regulator of Glucose Transport in Rat Skeletal Muscle*

@article{Hajduch1999SerotoninA,
  title={Serotonin (5-Hydroxytryptamine), a Novel Regulator of Glucose Transport in Rat Skeletal Muscle*},
  author={{\'E}ric Hajduch and Frank Rencurel and Anudharan Balendran and Ian H. Batty and C. Peter Downes and Harinder S Hundal},
  journal={The Journal of Biological Chemistry},
  year={1999},
  volume={274},
  pages={13563 - 13568}
}
In this study we show that serotonin (5-hydroxytryptamine (5-HT)) causes a rapid stimulation in glucose uptake by ∼50% in both L6 myotubes and isolated rat skeletal muscle. This activation is mediated via the 5-HT2A receptor, which is expressed in L6, rat, and human skeletal muscle. In L6 cells, expression of the 5-HT2A receptor is developmentally regulated based on the finding that receptor abundance increases by over 3-fold during differentiation from myoblasts to myotubes. Stimulation of the… Expand
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