Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat

@article{Morley2005SerotoninR,
  title={Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat},
  author={Kirsten C. Morley and Jonathon C. Arnold and Iain S. McGregor},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2005},
  volume={29},
  pages={648-657}
}

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

TLDR
The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.

A Behavioural Analysis of Serotonergic Functional Status Following MDMA Exposure

TLDR
The results support the idea that the 5-HT2a and 5- HT2c receptors that modulate MDMA-produced hyperactivity are functionally distinct from the receptors that mediate m-CPP- and DOI-induced behavioural responses, as m- CPP-produced behaviours were resilient, yet RS102221-induced effects were reduced, by MDMA pretreatment.

Examining the role of oxytocin in the interoceptive effects of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat

TLDR
The results of this study implicate oxytocin receptor activation as a key MDMA‐specific interoceptive cue in male and female rats and support the conclusion that this is one of the features of MDMA's subjective effects that distinguishes it from AMP.

Tolerance to the Behavioural and Neurochemical Effects of MDMA Following Repeated Exposure

TLDR
MDMA produced dose-dependent hyperactivity and tolerance was produced by MDMA pretreatment and rats were tolerant to the effects of MDMA and m-CPP two weeks following MDMA Pretreatment.
...

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