Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat

  title={Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat},
  author={Kirsten C. Morley and Jonathon C. Arnold and Iain S. McGregor},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.

A Behavioural Analysis of Serotonergic Functional Status Following MDMA Exposure

The results support the idea that the 5-HT2a and 5- HT2c receptors that modulate MDMA-produced hyperactivity are functionally distinct from the receptors that mediate m-CPP- and DOI-induced behavioural responses, as m- CPP-produced behaviours were resilient, yet RS102221-induced effects were reduced, by MDMA pretreatment.

Examining the role of oxytocin in the interoceptive effects of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat

The results of this study implicate oxytocin receptor activation as a key MDMA‐specific interoceptive cue in male and female rats and support the conclusion that this is one of the features of MDMA's subjective effects that distinguishes it from AMP.

Tolerance to the Behavioural and Neurochemical Effects of MDMA Following Repeated Exposure

MDMA produced dose-dependent hyperactivity and tolerance was produced by MDMA pretreatment and rats were tolerant to the effects of MDMA and m-CPP two weeks following MDMA Pretreatment.



Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats.

It is suggested that (+)MDMA increases locomotor activity via mechanisms that are dependent on the release of central 5-HT and that are qualitatively different from the mechanism of action of (+)amphetamine.

Behavioral profile of 3,4-methylenedioxy-methamphetamine (MDMA) in agonistic encounters between male mice

MDMA induced dopamine release in vivo: role of endogenous serotonin

It is concluded that 5-HT release after (+)-MDMA treatment partially contributes to (+-MDMA's effect on DA release in vivo, and the selective DA transport inhibitor GBR-12909 (1 μM), blocked (+)- MDMA’s effect onDA release.

The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Evidence for the occurrence of MDMA-induced neurotoxic damage in human users remains equivocal, although some biochemical and functional data suggest that damage may occur in the brains of heavy users.

Role of 5-hydroxytryptamine1B receptors and 5-hydroxytryptamine uptake inhibition in the cocaine-evoked discriminative stimulus effects in rats.

The results indicate that 5-HT1B receptors are not directly involved in the cocaine-induced discriminative stimuli in rats, and indicate that pharmacological stimulation of 5- HT receptors--that also seem to be a target for fluoxetine-mediated increase in5-HT neurotransmission--can enhance the overall effects of cocaine.

Acute and subchronic effects of MDMA (“ecstasy”) on anxiety in male mice tested in the elevated plus-maze

MDMA ("ecstasy") exhibits an anxiogenic-like activity in social encounters between male mice.

MDMA produced a behavioural pattern characterized by a marked decrease of aggression as well as social investigation, body care and digging behaviours, without affecting immobility, which might indicate that MDMA has anxiogenic-like properties in male mice.